To be clinically elegant is to seamlessly blend pharmacodynamics with pathophysiology.

25 September 2008

Which one of these isn't like the others?

A.




B.







C.






Can you tell which one of these doesn't belong, or which one is natural and which one is synthetic?... Neither can your body!

So many people it seems these days think (incorrectly) that there is something special about natural or herbal remedies, or that there is something inherently 'bad' about pharmaceuticals and manufactured chemicals. Your body's CYPs and transmembrane receptors metabolize or bind all of these substrates in the same way because they can't tell the difference between them. Compound (A) is norepinephrine an endogenous (naturally produced) neurotransmitter hormone. Substance (B) is Ma Huang or ephedrine; a.k.a. mormon tea, this is an herbal drug that releases endogenous norepinephrine. Finally, species (C) is pseudoephedrine a synthetic xenobiotic that performs the same function as ephedrine; causing the release of endogenous norepinephrine.

If the body can't tell the difference and there is no toxic effect why should it matter if the xenobiotic that you introduce into your body is 'natural', i.e. herbal or synthetic?

1 comments:

Sofia Deyanira said...

My first instinct is to disagree. Partly because the essence of natural medicine is holistic. It is to leave you feeling better about your body by treating it to milder substances. Maybe these molecules are recognized similarily, but something I know for sure is that your mentality about how your body will heal is very important, maybe even just as important as what you ingest. Matt taught me this.

Pharmacists don't get old, they just loose their potency.